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2019 CNS Cov Tshuaj Kho Mob Monotetrahexosylganglioside Sodium (GM1) Paj Hlwb (37758-47-7)

2019 CNS Cov Tshuaj Kho Mob Monotetrahexosylganglioside Sodium (GM1) Paj Hlwb (37758-47-7)

Meta piav qhia

Nrhiav kom paub txog lub luag haujlwm ntawm GM1 nyob rau hauv lub cev neurological, nws txoj kev laus los tiv thaiv, thiab cov kev mob tshwm sim nyob rau hauv nruab nrab thiab peripheral lub hlwb.

Monocalotexexylganglioside Solidum (GM1) yog dab tsi?

Monotetrahexosylganglioside sodium yog ib hom tshuaj neurotrophic uas nws tau ua yog GM1.

Gangliosides muaj rau chav kawm ntawm ganglio series, uas muaj ntawm ib qho glycosphingolipid nrog sialic acid residue ntawm qab zib saw. Qhov sib txuas ntawm cov roj polysaccharide sialated txuas nrog ceramide ntawm kev sib txuas ntawm β-glycosidic. Lawv tsis yog tsuas yog tsim nyob rau hauv cov paj hlwb plasmic neuronal tab sis kuj nyob hauv endoplasmic reticulum.

Txawm hais tias lawv ua rau 0.1% ntawm tag nrho qhov hnyav ntawm lub hlwb, gangliosides tus account rau yuav luag 10% ntawm tag nrho cov lipids. Lawv ntxias cov cell txawv, apoptosis, neuroprotection, thiab tso tawm cov neurotrophins.

Monotetrahexosylganglioside yog ib qho tsis zoo sib xws ntawm cov roj hmab oligosaccharide thiab ceramide. Lub molecule tuaj yeem pom ob qho tib si hydrophilic thiab lipophilic properties. Ua soluble nyob rau hauv cov dej thiab cov roj, Monocoletrahexosylganglioside tau yooj yim mus los ntawm cov ntshav-hlwb barrier.

Monotetrahexosylganglioside sodium GM1 plays lub luag haujlwm tseem ceeb hauv lub paj hlwb. Nws pom tias cov hlab ntsha puas ntsoog xws li kho cov kev puas hlwb, kev rov ua hauj lwm, thiab kev tsim kho cov hlab ntsha tom qab raug mob. Vim li no, Monotetrahexosylganglioside sodium yog kev pabcuam rau kev kho mob ntawm kev raug mob hauv lub cev. Qee qhov kev mob nkeeg muaj xws li cerebrospinal trauma, cerebrovascular puas tsuaj, thiab kev puas hlwb ntawm kev raug mob ntawm tes. Ntau ntawm nws muaj concentrated qhov muaj paj hlwb ntawm kev puas tsuaj.

Keeb kwm ntawm Monotetrahexosylganglioside Sodium (GM1)

Txoj kev tshawb no ntawm GM1 thiab nws txoj hauj lwm hauv neuroprotection hnub rov rau 1970s. Txij thaum ntawd los, cov kws tshawb fawb tau pom cov paj laum los ntawm kev siv cov kab lis kev cai ntawm tes thiab kev tshawb nrhiav tsiaj. Tag nrho cov kev sim tau npaj rau tsim qhov tseem ceeb ntawm GM1 nyob rau hauv neurodegenerative ntshawv siab.

Hauv 1986, los ntawm TRB SA, Monotetrahexosylganglioside sodium tau tso tawm nyob rau hauv lub npe lag luam, GM-1. Vim tias cov txiaj ntsig ntawm kev tshawb fawb txog tsiaj muaj kev cia siab, Teb Chaws Asmeskas cov kws kho mob tau teeb tsa los soj ntsuam Monotetrahexosylganglioside sodium (GM1) rau tib neeg. Cov ntsiab lus ntawm kev tshawb fawb tau cov neeg mob nrog CNS puas vim yog raug mob ntawm tus txha caj qaum, mob hlab ntsha tawg, Parkinson's disease, thiab Alzheimer.

Txij thaum ntawd los, lub xeev xws li Argentina thiab Ltalis tau pom zoo siv nws cov ntawv kho mob raws li ib txoj tshuaj kws kho mob siv rau kev kho mob ntawm cov mob nyhav neurological.

Monotetrahexosylganglioside Sodium(GM1)Lub hauv paus tsev kawm ntawv

Monotetrahexosylganglioside Sodium (GM1) npua hlwb (37758-47-7)

Monotetrahexosylganglioside Sodium(GM1) Specifications

CAS No. 37758-47-7
khoom npe Monotetrahexosylganglioside Sodium (GM1) Pig Lub hlwb
IUPAC Lub Npe (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Chav Kawm Tshuaj Sphingolipids
Melting Point 207 - 230 ° C
molecular Formula C77H139N3O31
Molecular pawg 1546.841 gmol-1
solubility · Dej
· Cov tshuaj yaj ywm soluble hauv methanol / chloroform
· Zej zom nyob hauv anhydrous ethanol
tsos Dawb mus rau xim dawb lyophilized hmoov
purity 98%
cia Kub -20 ° C
txee lub neej Ob xyoos
pH 5.0 rau 6.5
Synonyms · Monocalogioanoside GM1
·Ganglioside GM1

Monotetrahexosylganglioside Sodium(GM1) Mechanism of Action

Monotetrahexosyl ganglioside ua haujlwm ntau yam. Lub molecule yog thaj chaw ntawm feem ntau ntawm cov kev ua si ntawm lub cev.

Nyob rau hauv lub cell membrane ntawm lub hlwb, Monotetrahexosylganglioside kev ua haujlwm kom muaj kev sib luag nyob rau hauv thiab sab nraum daim ntawv membranous. Tsis tsuas yog nws txhawb ntxiv impermeability, tab sis nws tseem evens tawm sodium thiab calcium ions twj.

Nyob rau hauv cov ntaub ntawv ntawm paj hlwb raug, Monotetrahexosylganglioside sodium (GM1) los tiv thaiv lub qauv ntawm cov membranous. Nws trim cia cov kev ua ntawm phospholipase A2, moderates calcium ion influx, thiab txiav tawm ntawm cov dawb radicals.

Hlwb traumas ua kom nrov loj ntawm kev ua ntawm protein kinase nyob rau hauv lub hlwb, uas tej zaum yuav lav rau apoptosis. GM1 inhibits thiab reverses txoj kev no los tuav cov metabolism hauv cov nqaijrog hauv lub cytoplasm thiab keeb.

Tsis pub dhau lub mitochondrion, Monotetrahexosylganglioside ua hauj lwm kom upregulate qhov ATP thiab nws cov synthase kev ua. Nws kho tau ua puas tsuaj rau lub tshuab hluav taws xob thauj khoom thiab txhim kho oxidative phosphorylation. Yog li ntawd, lub hlwb lub hlwb mitochondrial tseem muaj kev noj qab haus huv.

Monotetrahexosylganglioside sodium txhaj tshuaj stimulates axonal sprouting los ntawm txoj kev loj hlob ntawm kev loj hlob rau lawv cov neeg txais kev pom zoo. Yam ntxim saib ntxim ua no rov ua rau cov hlab ntsha paj hlwb thiab txhawb nqa kev kho mob sai sai. Yog hais tias kev hloov zaum ob, tej zaum vim muaj kev puas tsuaj rau dopamine neuron, Monotetrahexosylganglioside yuav tswj cov nyhuv thiab txhim kho tus kabmob no.

2019 CNS Cov Tshuaj Kho Mob Monotetrahexosylganglioside Sodium (GM1) Paj Hlwb (37758-47-7)

Monocodexylganglioside Solidum (GM1) Teebmeem

Txawm hais tias gangliosides yog qhov tsawg tshaj plaws nyob rau hauv lub hlwb, lawv cov hauj lwm yog li ntawd loj. Cov lwg me muaj qhov zoo rau kev loj hlob, kev tsim kho, kho, thiab kev tiv thaiv ntawm cov hlab ntsha.

GM1 cia nrog hnub nyoog. Kev laus yog txuam nrog kev siv lub hlwb ntau, lub teeb kiv taub hau, qhov paj hlwb raug mob, los yog nco tsis zoo. Dhau li, muaj hnub nyoog mob loj xws li cerebral palsy, mob stroke, thiab dementia yuav tsis pop-up.

Kev ntxiv sijhawm ntawm exogenous GM1 pab tswj feem ntau ntawm cov laus syndromes. Qee qhov zoo Monotetrahexosylganglioside sodium (GM1) muaj xws li kev kho mob ntawm Alzheimer's tus kab mob, mob stroke, qaug dab peg, thiab cerebral palsy. Dhau li ntawd, qhov ntxiv ua rau kev laus zuj zus tuaj kev txhim kho kev nco.

Kev siv GM1 hauv kev siv tshuaj kho mob yog ib qho tseem ceeb heev. Piv txwv li, ntau lub teb chaws Europe thiab Asmeskas tau siv cov txiaj ntsig ntawm cov txiaj ntsig ntawm cov kab mob cancer hauv CNS.

Qhov ntxiv tau nce qhov kev loj hlob ntawm paj hlwb, kev loj hlob ntawm lub hlwb, thiab kev tiv thaiv ntawm kev puas siab puas ntsws. Therapeutically, no tawm ntawm cov qauv tawm hauv lub cev tawm cov kab mob hlwb, kev raug mob ntawm tuschem, mob paj hlwb hemorrhage, thiab kev raug mob paj hlwb raug mob.

Qhov tseem ceeb tshaj plaws nyob rau hauv txoj kev tshawb nrhiav thiab daim ntawv sau npe ntawm cov lus no rau tib neeg tau pom tias tsis muaj teebmeem Monotetrahexosyl ganglioside sodium (GM1).

Cov teebmeem GM1 tsis yog cov qauv tshwj xeeb. Nyob rau hauv 1976, Ceccarelli tau tsim tawm tias cov tawm tsam gangliosides ntxias lub nruab nrab thiab ib qho paj hlwb regeneration thiab kho ntawm cov hlwb puas. Qhov kev tshawb nrhiav tau tso lub hauv paus rau cov kws tshawb fawb uas pom kev txaus siab rau kev kawm txog lub luag haujlwm ntawm GM1 nyob rau hauv lub hauv paus paj hlwb.

Cov qhab-nees ntawm kev soj ntsuam pom tseeb tias Monocontralxosilganglioside tau muaj kev cuam tshuam rau kev loj hlob, txawv, kev loj hlob, thiab kev tsim kho tshiab ntawm cov leeg hlwb. Ntxiv mus, cov kev tshawb fawb rov qab ua kom tiav ntawm GM1 hauv neuroprotection, neuroplasticity, thiab kev sib kis ntawm kev sib txuas lus.

Yog hais tias muaj kev raug mob, kev noj tshuaj Monotetrahexosylganglioside sodium txhaj tshuaj yuav cuam tshuam rau cov kab mob hauv ob peb txoj hau kev. Lub molecule yuav tsis tsuas tsim lub dendritic tiam ntawm lub paj hlwb tiam sis kuj nce lawv cov ciaj nqi. Qhov thib ob, qhov ntxiv tau muaj txoj haujlwm tseem ceeb hauv kev kho, tsim ub no, thiab rov qab ua haujlwm.

Monotrahexosyl Ganglioside Solidum (GM1) Extract txoj kev

Li ntawd, nyob deb, Monotetrahexosyl ganglioside yog kev kho tsuas CNS uas yog ib txwm tshwm sim.

Lub molecule yog ib qho tivthaiv ganglioside, uas yog endogenously ua nyob rau hauv lub hlwb neural cell membrane ntawm hom tsiaj. Vim nws cov ntsiab lus nplua nuj nyob rau hauv cov nqaij ntshiv, cov kws tshawb fawb thiab cov kws kho mob tau txais thiab siv nws hauv kev npaj ntawm cov tshuaj monotetrahexose ganglion.

Peb rho tawm Monotetrahexosyl ganglioside los ntawm cov hlwb mammalian. Txawm hais tias koj muaj peev xwm cais tawm ntawm lub cev los ntawm ib tug los yog ib tug tshis, qhov zoo tshaj plaws txoj kev yog npua lub hlwb extract. Yog vim li cas thiaj li hais tias Monotetrahexosyl ganglioside extraction los ntawm oxen los yog tshis yuav feem ntau yuav kis cov kab mob kis tau zoo xws li cov kab mob nyuj thiab kab mob.

Cov ntaub ntawv raw li Monotetrahexosylganglioside sodium (GM1) kuaj cov kua qaub (extraction), yoojyim, thiab yig. Peb muab koj nrog tus nyab thiab ntshiab GM1 los ntawm npua plaw, raws li hom tsis kis kab mob rau tib neeg.

Rau siab yields, peb thov cov chloroform-methanol-dej extraction txujci. Tom qab ntawd, peb ua tiav ib qho kev hloov pauv thiab kev cais tawm ntawm kev cais tawm. Qhov no purification yields ib homogenous molecule, uas yog> 98% ntshiab los ntawm HPLC.

xaus

Cov teebmeem Monotetrahexosyl ganglioside yog qhov tseem ceeb hauv kev siv tshuaj. Nws yog ib qho tshuaj kws kho mob tau txais kev tso cai los tswj kev tswj cov kev puas hlwb thiab kev kho mob ntawm kev raug mob hauv lub cev.

Seb koj xav yuav GM1 rau kev siv lossis kev tshawb fawb, peb lav koj cov khoom qib siab. Peb ntim-tsim Monotetrahexosylganglioside sodium (GM1) hmoov raws li kev pom zoo cov qauv kev tswj hwm.

References

  1. Schneider, JS, Roeltgen, DP, li al. (1998). Parkinson's Disease: Ua Hauj Lwm Zoo Heev Nrog Kev Kho Mob Ganglioside GM1 nyob hauv kev tshawb nrhiav kev kawm hauv Randomized Placebo-Controlled.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, li al. (1994). IgM Ganglioside GM1 Antibodies nyob rau hauv cov neeg mob nrog kho kab mob autoimmune los yog Neuropathy, thiab tswj. Ntawv Tshaj Xo Tshuaj Kev Mob.
  3. Mocchetti, I. (2005). Exogenous Gangliosides, Neuronal Plasticity thiab Kho, thiab Neurotrophins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., et al. (2016). GM1 Ganglioside: Past Studies thiab Future Potential. Molecular Neurobiology.
  5. Bian, L., Yang, J., thiab Sun, Y. (2015). Kev Rho Tawm thiab Purification ntawm Monotetrahexosylgangliosides los ntawm Pig Lub Hlwb los ntawm Extraction thiab kua Chromatography.