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Yonghong Liang Ph.D. Cov Ntawv Kawm Vitae

Yonghong Liang Ph.D. Cov Ntawv Kawm Vitae

Ua tau zoo

Tshawb nrhiav kev tshawb nrhiav

  • Sep. 2006-Present Ua haujlwm rau Ph.D (Organic Chemistry)
    tej yaam num
    1. Kev tshawb nrhiav theoretical ntawm kev sib raug zoo ntawm dapivirine (TMC120) thiab HIV-1 rov qab transcriptase
    2. Quantitative qauv-kev sib raug zoo kev kawm txog benzyl hloov npe diarylpyrimidines
    3. Tsim, synthesis thiab SAR cov kev tshawb fawb ntawm α los sis β naphthyl substituted diarylpyrimidines li non-nucleoside inhibitors ntawm HIV-1 nrauv transcriptase
    4. Kev tsim thiab kev sib txuas ntawm DABOs raws li cov thawj cov kab mob HIV-1 ob sab transcriptase thiab kev cog lus

  • 2003-2006 Tus Neeg Kawm Ua Haujlwm
    tej yaam num
    1. 2-hydroxybenzophenone, xNUMX-hydroxy-8, 4-naphthoquinone, 1-hydroxy-5, 4-anthraquione, 5-Hydroxy, 1-hydroxy-9H-naphthalen-10-ib, hauv-thiab zoo siab-xeev intramolecular proton hloov -7-indenone, 1, 5-dihydroxy-8, 1-naphthoquinone), 4, 4-dihydroxyperylene-9, 3-quinone thiab hypocrellin A yog kawm los ntawm theoretical txoj kev.
    2. Hauv cov av-xeev inermolecular proton hloov hauv cov complexes ntawm 5-hydroxyisoxazole-dej, DNA (RNA) base dimer thiab puag-N-methylformamide tau ua los ntawm DFT txoj kev.
    2002-2003 Quantitative structure-Property kev sib raug zoo ntawm lub cuab tsiaj ntawm ketone thiab cov aldehyde

txeeb

Hunan Province excellence Master Thesis, 2008

Publications

1. Liang, YH; Chen, FE ONIOM DFT / PM3 cov kev laij leb ntawm kev sib raug zoo ntawm tus kheej thiab HIV-1 rov qab transcriptase, kev tshawb kawm theoretical. Tshuaj Txhaj Tshuaj. Ther. 2007, 1, 57-60.

2. Liang, YH; Chen, FE QSAR cov kev tshawb fawb rau diarylpyrimidines tawm tsam HIV-1 nraub qaum transcriptase qus-hom thiab mutant hom. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Design, Synthesis, thiab SAR ntawm Naphthyl-Hloov Lub Diarylpyrimidines li Non-Nucleoside Cov Txheej Txheem ntawm HIV-1 Reverse Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Kev hloov kho ntawm DAPY Analogs nrog Potential Anti-HIV-1 Kev Ua. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Kev txhim kho ntawm cov khoom noj khoom haus uas ua rau cov neeg tsis muaj kev sib koom tes ntawm HIV-1 rov qab transcriptase, ChemMedChem 2010, tau txais.

6. Liang, YH; Yi, PG Theoretical studies on structure, nquag thiab intramolecular proton hloov ntawm alkannin. Tshuaj Physics Lettters, 2007, 438, 173.

7. Liang, YH; Yi, PG; Peng, HL Theoretical txoj kev tshawb ntawm cov qauv, kev hloov nquag thiab hloov mus rau cov neeg tsis sib haum xeeb ntawm hypocrellin A. Tshuaj Physics Lettters, 2008, 466, 6-10.

8. Liang, YH; Yi, PG. Cao, CZ Kev tshawb nrhiav theoretical ntawm qhov kev pabcuam uas tau hloov proton hauv 5-hydroxyisoxazole. Phau Ntawv ntawm Cov Hom Phiaj Molecular: Theochem, 2005, 729, 163-167.

9. Yi, PG .; Liang, YH; Cao, CZ Intramolecular proton lossis hydrogen-atom hloov mus rau hauv av thiab zoo siab lub xeev ntawm 2-hydroxybenzophenone: Ib qho kev kawm theoretical. Tshuaj Physics, 2005, 319, 297.

10. Yi, PG .; Liang, YH Cov kev tshawb fawb theoretical ntawm conjugation thiab subsidiary teebmeem ntawm intramolecular proton hloov nyob rau hauv hauv av thiab zoo siab lub xeev. Tshuaj Physics, 2006, 322, 382.

11. Yi, PG .; Liang, YH Tang, ZQ Txoj kev tshawb kawm txog kev sib deev ntawm cov tshuaj proton hloov ntawm 5-hydroxyisoxazole-water complexes. Tshuaj Physics, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Parallel Synthesis thiab Kev Tshuaj Xyuas Kev Ntsuam Xyuas Diarylpyrimidines Muaj Kev Ua Haujlwm Muaj Mob HIV-1. Med. Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Kev tsim ntawm DABOs los ua ob tog tiv thaiv kab mob HIV-1 rov qab transcriptase thiab kev cog lus. J. Med. Chem.

14. Chen, FE, Liang, YH Tsis ntev los no txoj kev txhim kho rau lub phiaj xwm tshuaj tiv thaiv kab mob AIDS, Progess in Medical Chemistry (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC Tuam Tshoj, CN201110070027.4

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